<aside> 🟪 A knowledgebase of time-resolved matrisome signatures extracted from public proteomic datasets.
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<aside> 💵 5000 USD | ResearchHub
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The extracellular matrix is a complex substance localized in the extracellular space, serving as a medium where cells reside. Besides providing anchoring support, the extracellular matrix is a mechanical and biochemical environment that directs cellular functions and processes via a collection of various stimuli, prompting gene expression profiles to reflect developmental and physiological contexts. As a dynamic structure, the extracellular matrix composition is subject to change as a function of age. Presently, there is a lack of a unified consensual understanding of the qualitative and quantitative aspects of these changes. A few recent publications look into proteomic alterations that happen in the extracellular matrix of some tissues with aging. Consequently, aggregating the published datasets into a database of the extracellular matrix aging signatures is proposed.